Master’s Degree Awarded to Mr. Abdulnasser Aqlan in Pharmacology
Mr. Abdulnasser Saeed Ahmed Aqlan was awarded a Master’s Degree in Pharmacology with an average of excellent for his thesis titled: Evaluation of the Gastroprotective Effect of Alogliptin and Carpobrotus edulis Extract on Indomethacin-Induced Gastric Ulcers in Rats, which was submitted to the Department of Pharmacology and Therapeutics, Faculty of Medicine and Health Sciences – Sana’a University. The MA defense was held on Monday, May 11, 2026.
The MA Viva-voce Committee, which was formed based on a resolution issued by the Graduate Studies and Scientific Research Council, consisted of the following:
| # | Committee Members | Designation | Position |
| 1 | Prof. Hassan Mohammed Al-Mahbashi | Internal Examiner | Chair |
| 2 | Dr. Mohammed Abdulrahman Mohammed Al-Khawlani | Main Supervisor | Member |
| 3 | Assoc. Prof. Ali Abdullah Ahmed Al-Mahdhar | External Examiner | Member |
The thesis aimed to:
- Evaluate the potential gastroprotective effects of Alogliptin, Carpobrotus edulis extract, and their combination against indomethacin-induced gastric ulcers in rats.
The study yielded several key findings summarized as follows:
- Pretreatment with Carpobrotus edulis extract, Alogliptin, and their combination significantly reduced the number and severity of gastric ulcers.
- The combination therapy demonstrated superior protective effects compared to monotherapy, restoring GPx and SOD enzyme activities and reducing MDA levels, indicating attenuation of oxidative stress.
- Histopathological examinations confirmed reductions in necrosis, erosions, and inflammation in gastric tissues.
In light of these findings, the researcher recommended the following:
- Investigating the gastroprotective effects in alternative ulcer models, including ethanol-induced and stress-induced ulcers, to confirm the reproducibility of the findings.
- Evaluating the protective efficacy of Alogliptin and Carpobrotus edulis extract in diabetic rat models to better simulate the target patient population.
- Examining whether chronically used medications possess intrinsic gastroprotective effects that could reduce the need for additional medications and lower treatment costs.
The defense session was attended by a number of academics, researchers, students, colleagues, and the researcher’s family.
