Master’s Degree Awarded to Mr. Abdulnasser Aqlan in Pharmacology
Mr. Abdulnasser Saeed Ahmed Aqlan was awarded a Master’s Degree in Pharmacology with an average of excellent for his thesis titled: Evaluation of the Gastroprotective Effect of Alogliptin and Carpobrotus edulis Extract on Indomethacin-Induced Gastric Ulcers in Rats, which was submitted to the Department of Pharmacology and Therapeutics, Faculty of Medicine and Health Sciences – Sana’a University. The MA defense was held on Monday, May 11, 2026.
The MA Viva-voce Committee, which was formed based on a resolution issued by the Graduate Studies and Scientific Research Council, consisted of the following:
# |
Committee Members |
Designation |
Position |
1 |
Prof. Hassan Mohammed Al-Mahbashi |
Internal Examiner |
Chair |
2 |
Dr. Mohammed Abdulrahman Mohammed Al-Khawlani |
Main Supervisor |
Member |
3 |
Assoc. Prof. Ali Abdullah Ahmed Al-Mahdhar |
External Examiner |
Member |
The thesis aimed to:
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Evaluate the potential gastroprotective effects of Alogliptin, Carpobrotus edulis extract, and their combination against indomethacin-induced gastric ulcers in rats.
The study yielded several key findings summarized as follows:
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Pretreatment with Carpobrotus edulis extract, Alogliptin, and their combination significantly reduced the number and severity of gastric ulcers.
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The combination therapy demonstrated superior protective effects compared to monotherapy, restoring GPx and SOD enzyme activities and reducing MDA levels, indicating attenuation of oxidative stress.
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Histopathological examinations confirmed reductions in necrosis, erosions, and inflammation in gastric tissues.
In light of these findings, the researcher recommended the following:
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Investigating the gastroprotective effects in alternative ulcer models, including ethanol-induced and stress-induced ulcers, to confirm the reproducibility of the findings.
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Evaluating the protective efficacy of Alogliptin and Carpobrotus edulis extract in diabetic rat models to better simulate the target patient population.
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Examining whether chronically used medications possess intrinsic gastroprotective effects that could reduce the need for additional medications and lower treatment costs.
The defense session was attended by a number of academics, researchers, students, colleagues, and the researcher’s family.
