PhD Degree Awarded to Mr. Mohammed Ahmed Mujammal in Pharmacology
Mr. Mohammed Ahmed Ali Mujammal was awarded a PhD degree in Pharmacology and Therapeutics for his dissertation titled: Evaluation of the Potential Protective Effects of Allicin and Metformin against Doxorubicin-Induced Cardiotoxicity in Experimental Animal Models, which was submitted to the Department of Pharmacology and Therapeutics, Faculty of Medicine and Health Sciences– Sana’a University. The dissertation defense was held on Monday, April 13, 2026.
The PhD Viva-Voce Committee, which was formed based on a resolution issued by the Graduate Studies and Scientific Research Council, consisted of the following:
# Committee Members Designation Position
1 Prof. Hussein Omar Qadhi Internal Examiner Chair
2 Prof. Hassan Mohammed Al-Mahbashi Main Supervisor Member
3 Assoc. Prof. Khaled Mohammed Al-Akhali External Examiner Member
The dissertation aimed to:
Investigate the cardiotoxic effects of doxorubicin on cardiac tissue in animal models.
Analyze the protective role of metformin and allicin in reducing oxidative stress and associated cardiac damage.
The study yielded several key findings summarized as follows:
Doxorubicin causes a significant increase in cardiac injury markers and elevates oxidative stress levels, confirming its toxic effects on heart muscle.
Metformin and allicin contribute to improving antioxidant biomarkers and reducing indicators of cardiac damage.
Combined treatment with metformin and allicin produces an enhanced protective effect compared to the use of each compound individually.
In light of these findings, the researcher recommended the following:
Conducting further extensive studies using advanced techniques to validate the findings.
Expanding research on the molecular mechanisms associated with oxidative stress and inflammation.
Exploring the potential use of these compounds as adjunct therapies to mitigate cardiotoxicity under specialized medical supervision.
The dissertation defense was attended by a number of academics, researchers, and specialists, students, colleagues, and the researcher’s family.
