PhD Degree Awarded to Mr. Majdi Al-Samad in Pharmacology
Mr. Majdi Ali Al-Samad was awarded a PhD degree in Pharmacology for his dissertation titled: The Role of Gamma-Glutamyl Transpeptidase in Cisplatin- and Cyclophosphamide-Induced Nephrotoxicity in Experimental Animal Models, which was submitted to the Department of Pharmacology and Therapeutics, Faculty of Medicine and Health Sciences–Sana’a University. The dissertation defense was held on Monday, April 20, 2026.
The PhD Viva-Voce Committee, which was formed based on a resolution issued by the Graduate Studies and Scientific Research Council, consisted of the following:
# Committee Members Designation Position
1 Prof. Hussein Omar Qadhi Internal Examiner Chair
2 Prof. Hassan Mohammed Al-Mahbashi Main Supervisor Member
3 Prof. Mohammed Ali Al-Kamrani External Examiner Member
The dissertation aimed to:
Investigate the role of GGT enzyme in nephrotoxicity induced by Cisplatin and Cyclophosphamide.
Evaluate the effects of Amlodipine and Acetaminophen on kidney function, oxidative stress, antioxidant levels, and histopathological changes in experimental animals.
The study yielded several key findings summarized as follows:
Cisplatin induced severe nephrotoxicity, evidenced by significant elevation in kidney function markers and oxidative stress, along with a reduction in antioxidant levels, while Cyclophosphamide caused noticeable but less severe damage.
Amlodipine demonstrated a protective effect on the kidneys by reducing oxidative damage markers and improving renal function, whereas Acetaminophen exacerbated kidney injury.
Elevated levels of GGT were observed during chemotherapy treatment, indicating its central role as a contributing factor in drug-induced nephrotoxicity.
In light of these findings, the researcher recommended the following:
Adopting preventive strategies to protect kidney function during chemotherapy in order to reduce drug-induced side effects.
Exercising caution when using Acetaminophen concurrently with chemotherapy agents to avoid aggravating renal injury.
Conducting further studies on the potential protective role of Amlodipine in preventing nephrotoxicity during chemotherapy.
The dissertation defense was attended by a number of academics, researchers, and specialists, students, colleagues, and the researcher’s family.
