Master’s Degree Awarded to Mr. Abdulnasser Aqlan in Pharmacology
Mr. Abdulnasser Saeed Ahmed Aqlan was awarded a Master’s Degree in Pharmacology with an average of excellent for his thesis titled: Evaluation of the Gastroprotective Effect of Alogliptin and Carpobrotus edulis Extract on Indomethacin-Induced Gastric Ulcers in Rats, which was submitted to the Department of Pharmacology and Therapeutics, Faculty of Medicine and Health Sciences – Sana’a University. The MA defense was held on Monday, May 11, 2026.
The MA Viva-voce Committee, which was formed based on a resolution issued by the Graduate Studies and Scientific Research Council, consisted of the following:
# Committee Members Designation Position
1 Prof. Hassan Mohammed Al-Mahbashi Internal Examiner Chair
2 Dr. Mohammed Abdulrahman Mohammed Al-Khawlani Main Supervisor Member
3 Assoc. Prof. Ali Abdullah Ahmed Al-Mahdhar External Examiner Member
The thesis aimed to:
Evaluate the potential gastroprotective effects of Alogliptin, Carpobrotus edulis extract, and their combination against indomethacin-induced gastric ulcers in rats.
The study yielded several key findings summarized as follows:
Pretreatment with Carpobrotus edulis extract, Alogliptin, and their combination significantly reduced the number and severity of gastric ulcers.
The combination therapy demonstrated superior protective effects compared to monotherapy, restoring GPx and SOD enzyme activities and reducing MDA levels, indicating attenuation of oxidative stress.
Histopathological examinations confirmed reductions in necrosis, erosions, and inflammation in gastric tissues.
In light of these findings, the researcher recommended the following:
Investigating the gastroprotective effects in alternative ulcer models, including ethanol-induced and stress-induced ulcers, to confirm the reproducibility of the findings.
Evaluating the protective efficacy of Alogliptin and Carpobrotus edulis extract in diabetic rat models to better simulate the target patient population.
Examining whether chronically used medications possess intrinsic gastroprotective effects that could reduce the need for additional medications and lower treatment costs.
The defense session was attended by a number of academics, researchers, students, colleagues, and the researcher’s family.
